• 负责3个跨机构科研合作项目的管理工作，合作方为香港中文大学。共管理资金500万港币，并通过起草和执行资金管理策略，包括与销售人员制定销售协议，为两机构共节省20万元港币。管理过程中，按时以PPT和邮件方式向实验室负责人和合作伙伴汇报进程，并和合作方管理人员保持紧密联系以确保项目的顺利进行以及项目目标的完成。 • 管理3组由2到4名本科和博士生组成的研究团队，负责沟通解决项目进行中出现的人事纠纷和技术性问题，并对科研问题给予专业指导。修改4篇由作者拟好的英文学术文章并辅助文章在国际期刊的顺利发表。 • 管理科研数据。 Managed 3 cross-organizational projects with total government grants worth of HK$5 million • Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction • Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations • Monitored progress and ensured projects meet deadlines in a timely and accurate fashion • Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved • Negotiated with venders and achieved business agreements • Provided regular updates on progress to lab director and collaborators through data presentations and written reports • Provided expertise on study design and research methodology • Troubleshooted experimental and technical problems • Managed and securely stored data • Reviewed 4 articles intended for publication in internally recognized journals • 建立两个可以用于商业化的 CRISPR-Cas9 基因敲除稳定细胞系。 • 建立了3个新型激酶在人体内的作用对象的数据库，并完善了利用概率来筛选和分析蛋白分子互动对象的数学方法。 • 设计并完成关于几类新型激酶在卵巢癌和肝癌的发展和转移中所起作用的研究，其中，明确确定了SBK1激酶在卵巢癌发展中的作用。研究中运用到生物细胞学、生物化学、蛋白学、统计学和动物模型等实验方法。 • 与学院内蛋白小分子、干细胞等实验组以及香港中文大学某实验室取得了合作，并带领、辅导2支国外本科交流实习生队伍参与与此课题相关的实验。 • 起草并提交实验室科研经费申请。 Led a large-scale research project to investigate the activities of previously unknown kinases in ovarian and hepatic cancer • Generated 2 CRISPR-Cas9 stable gene knockout cell lines available for commercial use • Developed a probability-based algorithm to screen and analyze protein inter candidates • Established kinase targets databases for 3 novel kinases • Verified the mechanism of novel gene SBK1 in ovarian cancer metastasis • Mentored 2 groups of international undergraduate interns • Collaborated with teams in FHS and the Chinese University of Hong Kong • Prepared and submitted proposals for grant applications in line with group strategies • Executed a series of experiments on protein characterization, protein-protein inter and functional assays in vitro and in vivo

• 建立了与包括加拿大国家中子中心、 劳厄-朗之万研究所（法国）、Helmholtz-Zentrum Berlin（HZB德国）、巴斯大学、拉塞福-阿普顿实验室、格拉斯哥大学和罗斯林研究所（英国）在内的7所国际知名科研中心的学术合作，并多次获得中子机构给予的科研经费。期间与10多个由多学科人员组成的当地团队一起工作，与主要人员建立了长期合作关系。 • 通过物理学和数据分析来研究艾滋海默症病理。物理学采用包括光学、分子运动学和中子衍射等一系列物理学原理来学习该病病原淀粉样蛋白的物理结构及结构变化，以及该蛋白在不同结构下对细胞磷脂层的作用；数学主要应用傅立叶变化将由中子衍射发出的信号转变为磷脂分子模型，进而分析磷脂在淀粉样蛋白作用下的变化。博士毕业论文：淀粉样蛋白和磷脂细胞的相互作用关系。 • 创立了体外控制淀粉样蛋白聚集的方法。 • 改进并完善了利用Langmuir膜和布鲁斯特角显微镜来观测磷脂单分子层在水与空气交接面的状态的方法。 Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics Thesis title: The inter between Amyloid beta peptide and lipid membranes • Established collaborations with 7 world-renowned institutes including Canadian Neutron Beam Centre, The Institute Laue-Langevin, Helmholtz-Zentrum Berlin, University of Bath, Rutherford on Laboratory, University of Glasgow and the Roslin Institute • Worked in 10+ multidisciplinary teams in Europe and Canada to identify the structural characteristics of amyloid protein and the biophysics of protein-lipid inters received neutron beam time al and traveling grants from neutron scattering facilities • Performed mathematical analysis based on Fourier transform to generate membrane profile from neutron diffr data sets and predict protein penetration position • Created a novel methodology to protein folding rate in non-physiological environments • Improved Langmuir trough and Brewster Angle Microscopy techniques to monitor lipid mono dynamics at air-water interface

应用物理和数学方法学习阿兹海默症病理/ Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics

兽医病理学/ Veterinary Pathology 兽医临床/ Veterinary Surgery 生物/ Biology 有机化学/ Organic Chemistry

负责3个跨机构科研合作项目的管理工作，合作方为香港中文大学，共管理资金500万港币/ Managed 3 cross-organizational research projects with total government grants worth of HK$5 million

• 通过起草和执行资金管理策略，包括与销售人员制定销售协议，为两机构共节省20万元港币。管理过程中，按时以PPT和邮件方式向实验室负责人和合作伙伴汇报进程，并和合作方管理人员保持紧密联系以确保项目的顺利进行以及项目目标的完成。 • 管理3组由2到4名本科和博士生组成的研究团队，负责沟通解决项目进行中出现的人事纠纷和技术性问题，并对科研问题给予专业指导。修改4篇由作者拟好的英文学术文章并辅助文章在国际期刊的顺利发表。 • 管理科研数据。 • Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction • Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations • Monitored progress and ensured projects meet deadlines in a timely and accurate fashion • Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved • Negotiated with venders and achieved business agreements • Provided regular updates on progress to lab director and collaborators through data presentations and written reports • Provided expertise on study design and research methodology • Troubleshooted experimental and technical problems • Managed and securely stored data • Reviewed 4 articles intended for publication in internally recognized journals